Yariv Wine

Yariv Wine’s research focuses on the complex dynamics of the adaptive immune response in both healthy and diseased states. During his doctoral studies, he explored the complexities of protein-protein interactions, particularly in engineering novel composite materials within the nano-biotechnology sphere. His postdoctoral fellowship at the University of Texas, Austin, under the mentorship of Prof. George Georgiou, allowed him to pioneer advanced methodologies for analyzing the humoral response triggered by vaccinations or disease. These methodologies have since been adopted by numerous research entities to decode the humoral response in diverse clinical contexts. Since establishing his laboratory at Tel Aviv University, he has led a multifaceted research agenda with a strong focus on anti-bacterial solutions. He and his team are advancing the understanding of maternal-infant immunity by examining the molecular composition, evolution, and functional properties of maternal, trans-placental, and breastmilk vaccine-specific B cells and antibodies. Additionally, he is at the forefront of developing anti-bacterial monoclonal antibodies poised to serve as the next generation of antibiotics and diagnostic tools. His translational research also includes immunogenicity profiling of therapeutic monoclonal antibodies, the study of anti-drug antibodies, and elucidating the role of B cells within the tumor microenvironment.

The primary aim of his lab’s work is to bridge basic immunological research with practical applications, particularly in developing anti-bacterial therapies and diagnostic platforms. This includes vaccine evaluation, immunodiagnostic point-of-care solutions, and the discovery and refinement of monoclonal antibodies.